Based on Larry McMurty's best-selling novel, Buffalo Girls celebrates the bold escapades of tough-talking Calamity Jane and her illustrious cohorts. It's the waning days of the Wild West and Jane (Anjelica Huston), the rough 'n' rugged cowgirl, is searching not only for her long-lost daughter, but the Wild West she once knew. Jane's unforgettable adventure traverses plains, mountains and continents until she finally discovers the answer to her problem: Dora (Melanie Griffith), the vivacious, gold-hearted madame who's been her one true friend all along.